Cold adapted variants of influenza A
Identifieur interne : 002A97 ( Main/Exploration ); précédent : 002A96; suivant : 002A98Cold adapted variants of influenza A
Auteurs : S. B. Spring [États-Unis] ; H. F. Maassab [États-Unis] ; A. P. Kendal [États-Unis] ; B. R. Murphy [États-Unis] ; R. M. Chanock [États-Unis]Source :
- Archives of Virology [ 0304-8608 ] ; 1977-09-01.
English descriptors
- Teeft :
- Biological characterization, Clone, Cold adaptation, Cold recombinants, Cold reeombinants, Cold variant, Cold variants, Genetic analysis, Genetic stability, Hamster, Hamster lung, Hamster lungs, Influenza, Influenza virus, Lesion, Mutant, Nasal, Nasal turbinates, Plaque, Plaque formation, Recombinant, Recombinant viruses, Recombination, Reeombinants, Replication, Revertants, Sufficient virus, Tissue culture, Turbinate, Vaccine, Variant, Virology, Virus, Wild type.
Abstract
Summary: The genetic and biological properties of 13 recombinant influenza A clones derived at 25°C from the A/AA/6/60-cold variant (by crosses with 4 different wild type strains) were compared with a set of 5-FU inducedts-mutants. The 5-FU mutants had previously been placed into 7 complementation-recombination groups; the A/AA/6/60-cold parent (PI-7) and the 12 cold recombinant clones which werets were shown to share a lesion with only one of these groups. The parental strain and 5 recombinant clones were evaluated for replication in the lungs and nasal turbinates of hamsters. Each virus appeared to be attenuated; genetic stability correlated with the level of viral replication in the hamster lung, i.e., viruses which grew best showed a tendency to revert to thets + phenotype. Characterization of thets + revertants for the presence of the cold adaptation property revealed that these viruses exhibited a spectrum of cold adaptation properties. Two viruses, PI-7 (the parental cold variant) and the CR6 recombinant (A/Queensland/6/72) did not revert in either the lungs or nasal turbinates of hamsters.
Url:
DOI: 10.1007/BF01319909
Affiliations:
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Chanock</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Archives of Virology</title><title level="j" type="abbrev">Archives of Virology</title><idno type="ISSN">0304-8608</idno><idno type="eISSN">1432-8798</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><date type="published" when="1977-09-01">1977-09-01</date><biblScope unit="volume">55</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="233">233</biblScope><biblScope unit="page" to="246">246</biblScope></imprint><idno type="ISSN">0304-8608</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0304-8608</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Biological characterization</term><term>Clone</term><term>Cold adaptation</term><term>Cold recombinants</term><term>Cold reeombinants</term><term>Cold variant</term><term>Cold variants</term><term>Genetic analysis</term><term>Genetic stability</term><term>Hamster</term><term>Hamster lung</term><term>Hamster lungs</term><term>Influenza</term><term>Influenza virus</term><term>Lesion</term><term>Mutant</term><term>Nasal</term><term>Nasal turbinates</term><term>Plaque</term><term>Plaque formation</term><term>Recombinant</term><term>Recombinant viruses</term><term>Recombination</term><term>Reeombinants</term><term>Replication</term><term>Revertants</term><term>Sufficient virus</term><term>Tissue culture</term><term>Turbinate</term><term>Vaccine</term><term>Variant</term><term>Virology</term><term>Virus</term><term>Wild type</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: The genetic and biological properties of 13 recombinant influenza A clones derived at 25°C from the A/AA/6/60-cold variant (by crosses with 4 different wild type strains) were compared with a set of 5-FU inducedts-mutants. The 5-FU mutants had previously been placed into 7 complementation-recombination groups; the A/AA/6/60-cold parent (PI-7) and the 12 cold recombinant clones which werets were shown to share a lesion with only one of these groups. The parental strain and 5 recombinant clones were evaluated for replication in the lungs and nasal turbinates of hamsters. Each virus appeared to be attenuated; genetic stability correlated with the level of viral replication in the hamster lung, i.e., viruses which grew best showed a tendency to revert to thets + phenotype. Characterization of thets + revertants for the presence of the cold adaptation property revealed that these viruses exhibited a spectrum of cold adaptation properties. Two viruses, PI-7 (the parental cold variant) and the CR6 recombinant (A/Queensland/6/72) did not revert in either the lungs or nasal turbinates of hamsters.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Maryland</li><li>Michigan</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Spring, S B" sort="Spring, S B" uniqKey="Spring S" first="S. B." last="Spring">S. B. Spring</name></region><name sortKey="Chanock, R M" sort="Chanock, R M" uniqKey="Chanock R" first="R. M." last="Chanock">R. M. Chanock</name><name sortKey="Kendal, A P" sort="Kendal, A P" uniqKey="Kendal A" first="A. P." last="Kendal">A. P. Kendal</name><name sortKey="Maassab, H F" sort="Maassab, H F" uniqKey="Maassab H" first="H. F." last="Maassab">H. F. Maassab</name><name sortKey="Murphy, B R" sort="Murphy, B R" uniqKey="Murphy B" first="B. R." last="Murphy">B. R. 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